Canonical Response Parameterization: Quantifying the structure of responses to single-pulse intracranial electrical brain stimulation
Fig 6
Illustrative examples of extraction significance.
A. An example of a high noise, but highly significant voltage response. B. An example of no significant response to stimulation. C. Early significance is detected in an apparently insignificant response. D. Examination of the voltages prior to t1 shows a clear (presumably artifactual) offset, explaining the observation in (C). E. An example of significance throughout a response that appears to be insignificant, though does have a non-zero offset. F. Correcting (E) for the 20μV offset in baseline removes the artifactual significance. Note that p-values determined by t-test of vs 0.