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Canonical Response Parameterization: Quantifying the structure of responses to single-pulse intracranial electrical brain stimulation
Fig 3
Using time-resolved projection weight to quantify response duration, τR.
A. Stimulation and recording sites for this example, shown in a sagittal MRI section. B. 10 single trials of stimulation response (gray) produced the averaged evoked potential shape (black). C. Abbreviated timeseries are calculated from t1 to a range of t2s to obtain time-resolved projection weights (individual dots). The traces above indicate a subset of the projections (for the normalized trace of 9th trial) at times t2 = 20ms, t2 = 80ms = τR, t2 = .5s, and t2 = 1s, with distributions of 
at each of these timepoints highlighted in the light red background. In this example, the blue dots are projection of the normalized trace of 9th trial (illustrated in traces above). The thick black line is 
. Calculated response duration, τR, is indicated by a red circle. Small vertical red lines indicate thresholds where 
exceeds 98% of 
(providing an estimate of the error in calculating τR). Note that blue dots in bottom portion are the projections illustrated for the 9th trial from the traces on the top. D. The projection weight temporal profile, from the black line in the lower portion of (C), is shown with a gray line. The averaged voltage response, from the black line in (B), is shown with a black line, and the significant portion of the response is highlighted (i.e. up to τR). E. As in (D), but for the example response from Fig 2.
doi: https://doi.org/10.1371/journal.pcbi.1011105.g003