Comparative Clustering (CompaCt) of eukaryote complexomes identifies novel interactions and sheds light on protein complex evolution
Fig 8
Overview of CompaCt output cluster containing subunits from the membrane component (V0) of the Vacuolar ATPase complex (V-ATPase) in H. sapiens, Y. lipolytica, A. thaliana and P. falciparum complexomes.
Clustered proteins with a fraction clustered score of over 0.5 or best hit homologs with those are displayed. Proteins in columns are orthologs or best hit homologs, and are labeled depending on whether they have previously been associated with this protein complex. Two or more proteins in the same block indicate likely gene duplications. For proteins labeled as “associated with the complex” there is some previous evidence associating them with the V-ATPase complex, while for the other proteins there is not.