Comparative Clustering (CompaCt) of eukaryote complexomes identifies novel interactions and sheds light on protein complex evolution
Fig 2
Overview of clusters resulting from CompaCt analysis of a collection of complexome profiling datasets.
Each dot corresponds to an MCL supercluster, with dot size corresponding to the number of subclusters (e.g., species) consistently represented in this cluster. The x-axis represents the number of proteins consistently represented in the cluster. The cluster coherence score displayed on the y-axis is a measure for the degree of commonality between the clustered proteins per dataset. Various clusters that we identified to correspond to known protein complexes have been annotated in the figure as such. Note that the cluster consisting mainly of ras-related proteins is unlikely to represent a large complex, as the comigration of multiple members of this protein family is most likely caused by their similar mass.