Pupillary response is associated with the reset and switching of functional brain networks during salience processing
Fig 3
Functional connectivity (FC) across salience processing nodes (group averaged z-score, mixed-effect, p < 0.05 uncorrected).
fMRI BOLD signals from the nodes (intersected with the gray matter mask) were extracted, controlling the nuisance signals (motion-related, ventricle and white matter signals). Pearson’s correlation was calculated between BOLD signals from the nodes (with the task-related variability regressed out). FC results identified three distinct groups of the nodes, organized by the EEG discriminating component time windows, indicating a temporal network organization of the nodes: 1) early-time network includes lSPL and rSPL, rM1, rV2, and lS1; 2) middle-time network includes lOFC and rOFC, lIPL, and rIFC; 3) late-time network includes mPFC, SMA, left frontal operculum and temporal pole.