Pupillary response is associated with the reset and switching of functional brain networks during salience processing
Fig 2
Network localization approach to map functional networks underlying salience processing nodes.
(A) BOLD signals from the nodes (intersected with the gray matter mask) were extracted, controlling the nuisance signals (motion-related, ventricle, and white matter signals). (B) Group-level functional connectivity (FC) results of each node (t-value, mixed-effect, p < 0.001 uncorrected). Seed-based FC analysis (with the task-related variability regressed out) was used to map network of regions connected to each node location. Colors denote positive (red) and negative (blue) correlations. (C) Spatial overlaps in the FC maps of each node identified spatial network organizations of salience processing nodes. Colors represent the number of FC maps overlapped. lSPL and rSPL, left and right superior parietal lobule; rM1, right primary motor cortex; lS1, left primary somatosensory cortex; rV2, right secondary visual area; lOFC and rOFC, left and right orbitofrontal cortex; lIPL, left inferior parietal lobule; rIFC, right inferior frontal cortex.