Partial correlation network analysis identifies coordinated gene expression within a regional cluster of COPD genome-wide association signals
Fig 7
COPD Candidate Genes are present in the differential partial correlation network.
An edge between two genes is present if the two genes are significantly differentially partially correlated (FDR<0.1). (a) The number of significant edges obtained for each set of parameters. (b) The histogram showing how frequently an edge was significant in the partial correlation networks estimated using different parameters. The edge with the highest frequency is (CXCL10-CXCL11). (c) The network obtained by edges present in the partial correlation with >1 controlling genes (n_genes). The edge color is the average partial correlation difference obtained with all of the examined parameters. Blue edges represent pairs of genes that are more positively correlated in the control subjects, red edges represent pairs of genes that are more correlated in COPD subjects. COPD Candidate Genes (CCG) are highlighted with a dark green outline.