Shadow enhancers mediate trade-offs between transcriptional noise and fidelity
Fig 6
Duplication of subadditive enhancers can increase transcriptional fidelity and reduce noise.
(A) Single enhancer models and those that result from repeated enhancer duplications. (B) Plots showing the relationship between total binding sites and enhancers for the case of enhancer splitting and enhancer duplication. Splitting does not affect total binding site numbers while it increases enhancer numbers. On the other hand, duplication increases both enhancer numbers and total binding sites at different rates. (C) Plots depicting transcriptional fidelity and noise for subadditive versions of the models in (A). Enhancer duplications increase transcriptional fidelity while the noise generally decreases.