Shadow enhancers mediate trade-offs between transcriptional noise and fidelity
Fig 3
In subadditive enhancers, noise increases with enhancer number but fidelity is broadly unchanged.
(A) Subadditivity is implemented in our model by linearly decreasing kon rates and linearly increasing koff rates. In this case d1, the rate of decrease for kon, was chosen to be 0.04 for T1 and 0.02 for T2. Meanwhile d2, the rate of increase for koff, was chosen to be 0.75 for both T1 and T2. (B) Systems with more subadditive enhancers tend to exhibit higher noise, while the fidelity is broadly independent of enhancer number. Noise and fidelity are also independent of binding site distribution but vary with respect to the number of binding sites. (C) Plots showing the relationship between binding site numbers and transcriptional noise for two subadditive enhancers.