Shadow enhancers mediate trade-offs between transcriptional noise and fidelity
Fig 2
Under additive assumptions, transcriptional fidelity and noise are independent on enhancer number but depend on TF binding site number.
(A) Different enhancer models used in the simulations. Each model has different total binding sites for T1, total binding sites for T2, distribution of binding sites, and number of enhancers. (B) Simulations for the models in (A) show that fidelity and noise are independent of the number of enhancers and the distribution of binding sites. The noise broadly decreases as a function of total TF binding sites, while fidelity with respect to T1 increases with the number of T1 binding sites. The table on the right shows the fidelity and noise values for two different configurations of TF binding sites among two enhancers. (C) Noise calculated as functions of the total binding sites for T1 or T2. As the total number of binding sites increases, the noise generally decreases.