MitoTNT: Mitochondrial Temporal Network Tracking for 4D live-cell fluorescence microscopy data
Fig 6
Temporal characteristics of mitochondrial network remodeling, flux, and damage resilience.
a, Temporal networks display node and edge dynamics that have an influence on network transport and resilience (newly added or removed nodes/edges highlighted in red). b, Mean degree difference between control, oligomycin, and nocodazole. c, Temporal intersection between control, oligomycin, and nocodazole. d, Global network reachability in a representative somatic mitochondrial network depicted as a color gradient (dark: high reachability, light: low reachability). e, Global network reachability where the top 5% highest betweenness-centrality nodes were removed. f, Mean normalized global reachability in different drug conditions. The three violin plots for each condition correspond to no nodes removed (left), 5% random nodes removed (middle), and 5% most connected nodes removed (right). g,h, Correlation of network reachability with node MSD and temporal intersection.