Quantifying cooperative multisite binding in the hub protein LC8 through Bayesian inference
Fig 6
binding between the intermediate chain (IC) and NudE.
(a) A model of NudE-IC binding, which forms a 2:2 complex. A cartoon diagram of NudE is shown in purple and IC in orange. (b) Sampled distributions modeled from a ‘global’ model based on two isotherms for binding between IC and NudE from yeast. Marginal distributions for thermodynamic parameters are shown on the left, and the top right corner contains the experimental isotherms (points) with model values (lines) drawn from the posterior.