Repetitive transcranial magnetic stimulation (rTMS) triggers dose-dependent homeostatic rewiring in recurrent neuronal networks
Fig 2
Repetitive transcranial magnetic stimulation (rTMS) changes network activity in a static network.
(A) Illustration of the recurrent neuronal network with sparsely connected excitatory [E] and inhibitory [I] neurons used in this study. A subset of excitatory neurons [S] is stimulated. (B) rTMS influences the firing state of the stimulated neurons [S], causing them to fire in a more synchronous manner. (C) Change in the average firing rate in response to different stimulation intensities and frequencies of 10% of excitatory neurons. Four intensities (a: weak, c: peak, d: strong, and b: strong-equivalent) were selected to represent different stimulation intensities. (D) Firing rate histograms for populations E, I, and S at stimulation intensities a, b, c, and d, respectively. (E) Heatmaps summarizing the response of stimulated neurons to rTMS applied to 10% (top) and 30% (bottom) of excitatory neurons.