Repetitive transcranial magnetic stimulation (rTMS) triggers dose-dependent homeostatic rewiring in recurrent neuronal networks
Fig 1
Transcranial magnetic stimulation (TMS) has an immediate effect on the membrane potential dynamics of single neurons.
(A) Schematic illustration of TMS in humans and neurons. The TMS-induced electric fields cause depolarization of neurons in the target region. We implemented TMS as rectangular pulse current injections with a duration of 0.5 ms (c.f., output parameters of conventional TMS devices). (B) Single stimuli produce changes in the membrane potential in a dose-dependent manner. (C) A linear relationship is evident between applied effective stimulation strength (in nA) and the resulting membrane potential deviation, as predicted by Ohm’s law (See Methods). (D) Suprathreshold stimulation at different frequencies elicits spiking responses from the stimulated neurons. Created with BioRender.com.