Combining phylogeny and coevolution improves the inference of interaction partners among paralogous proteins
Fig 5
Robust performance of GA-IPA in hard cases of paralog pairing.
(A) Same as Fig 4 but on a dataset having on average 29.2 paralogs per species, compared to 11.03 in Fig 4. While the performance of GA is substantially reduced compared to Fig 4, and that of IPA is even more reduced, GA-IPA achieves much larger TP fractions than GA and IPA. (B) Results of GA, IPA and GA-IPA for smaller datasets obtained by species subsampling from the full HK-RR data set, with 11.1 paralogs per species on average. We observe that GA-IPA needs almost one order of magnitude less sequences than IPA to reach comparable TP fractions.