Model certainty in cellular network-driven processes with missing data
Fig 7
Posterior predictions of aEARM trained to published fractional cell death data.
A. Fractional cell death in WT (blue) and high- and low- expression of dominant negative FADD (green and orange respectively) in HeLa cells treated with 0 to 200ng/mL TRAIL. These data come from Wajant et al. 1998 [29]. The aEARM and accompanying measurement model were calibrated to these data. B. The posterior predictions of the Gaussian process modeled mean fractional cell death values for WT and high- and low- expression of dominant negative FADD in HeLa cell treated with 0 to 200ng/mL TRAIL. C. Posterior predictions of the Gaussian process modeled mean fractional cell death values for WT and BID overexpressed (TAT-Bid) HeLa cells treated with and without 100ng/mL TRAIL. Fractional cell death predictions for these experimental conditions, which were excluded from our training dataset, correspond to fractional cell death measurements by Orzechowska et al [30]. The 95% credible region of the posterior prediction (D.) of tBID dynamics in cells treated with 25g/mL TRAIL. (E.) Posterior distributions of the weight for each feature extracted from tBID dynamics.