Model certainty in cellular network-driven processes with missing data
Fig 4
Predicted Bid truncation dynamics of aEARM trained to nominal and ordinal datasets.
A.) Nominal cell death (x) vs survival (o) outcomes data for cells treated with 10ng/mL (orange) and 50ng/mL (grey) of TRAIL and with known relative values of DISC formation (x-axis). The 95% credible region (shaded region) of posterior predictions of tBID dynamics of aEARM calibrated to nominal data (right plot). The median prediction (solid-line) and true (dotted line) are also plotted. B.) Ordinal measurements for initiator caspase-DISC colocalization (IC-DISC) at 300s intervals (left plot). The 95% credible region (shaded region) of posterior predictions of tBID dynamics of aEARM calibrated to ordinal IC-DISC data (right plot), and C.) of aEARM calibrated to nominal and ordinal IC-DISC data. The median prediction (solid-line) and true (dotted line) were also plotted. The fit to IC-DISC data is shown in Fig G S1 Text.