Laminar specificity of the auditory perceptual awareness negativity: A biophysical modeling study
Fig 3
Current dipoles and laminar profiles.
(A) HNN simulation for the average response to the undetected target tones (dark blue trace). Input spikes are sampled from a Gaussian distribution on each trial for a total of 10 trials (gray traces). A proximal input (47.8 ms) followed by a distal input (84.3 ms) drive the network. R2 between empirical (light blue trace) and simulated data (dark blue) is 0.57 and RMSE is 0.61 nAm. (B) HNN simulation for the average response to detected target tones (dark orange traces). The same proximal and distal inputs used to model the response to undetected target tones, and an additional distal input (169.3 ms), drive the network. R2 between empirical (light orange trace) and simulated data (dark orange) is 0.95 and RMSE is 0.63 nAm. (C-D) Laminar profiles for the responses to the undetected and detected target tones. The contribution of layer 2/3 (which reflects the longitudinal currents in layer-2/3 (L2/3) pyramidal neurons only) is plotted in green and that of layer 5 (which reflects the longitudinal currents in L5 pyramidal neurons only) in magenta. Note that the model traces in panels A and B reflect the aggregate of the green and magenta traces in panels C and D. The corresponding input parameter values are displayed in Fig 4. The network from which the simulated dipole activity arises consists of 60,000 cells.