Uncovering the organization of neural circuits with Generalized Phase Locking Analysis
Fig 8
Application to electrophysiological recordings in non-human primate PFC.
(A) Location of the Utah array, anterior to the arcuate sulcus (red line) and inferior to the principal sulcus (green line). (B) Broadband trace of the recorded LFP (from the recording channels indicated in C). (C) Utah array spatial map identifying channel IDs shown in B. (D) Spike rasters for all recorded neurons. (E-F) Example spike trains (red bars) and filtered LFP (black traces) in the frequency ranges (E) 3–5 Hz and (F) 15–30 Hz. (G) gPLV values. Triangles indicate the significance assessed based on surrogate (blue triangles) and analytical test (red triangles) tests. (H) Phase of spike vector coefficients as a function of its modulus for the frequencies indicated in the legend (one dot per coefficient, continuous lines indicate linear regression). (I-K) LFP and spike vectors for frequency (I) 3–5 Hz, (J) 5–15 Hz, and (K) 15–30 Hz. The first column depicts the LFP (blue dots) and spike (red dots) in the complex plane. The second column depicts the fitted von Mises distribution to phase of LFP and spike vectors. Third and forth columns respectively represent the spatial distribution of phase of LFP and spike vectors values on the array (see C). White pixels in the third column (LFP vector) indicate the recording channels that were not used in the recording and in the fourth column (spike vector), white pixels indicate the recording channels with insufficient number of spikes (multiunit activity with a minimum of 5 Hz firing). In the last two columns, colors are represented in HSV mode, in which a complex number (reiϕ) is represented by hue and brightness of a pixel. The hue of a pixel indicates the phase (ϕ) and the brightness of a pixel indicates the modulus (r). The colorbar is depicted on the right. Related supplementary Figure: S7 Fig, Analysis of PFC Utah array data.