Uncovering the organization of neural circuits with Generalized Phase Locking Analysis
Fig 2
Illustration of GPLA on simple simulations.
(A) Normalized amplitude of LFP-like oscillatory signals. (B) gPLVs for different models demonstrated in C-F (C-F) Various scenarios of spike-LFP coupling. Left: schematic representation of the modulating LFP oscillation (circle), and 6 representative neuron-like-units (indicated by the triangles). The color of each connecting line indicates the locking phase (see bottom colorbar for color code). Center: LFP-like signals within the window specified by the blue box in A and spikes are represented by overlaid red vertical lines. Right: resulting spike vector is represented in the third column. (C) Spiking activity globally synchronized to the trough of the LFP oscillation. (D) Sequential discharge of spikes coupled to the LFP. (E) Three clusters of neurons discharge at different phases of the LFP oscillation (a similar model was also used in Fig 3). (F) Spiking activity uncoupled to LFP oscillation (independent homogeneous spike trains). Also see Table A in S1 Appendix for a methodological summary.