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Elucidation of genome-wide understudied proteins targeted by PROTAC-induced degradation using interpretable machine learning

Fig 4

Protein kinase tree based on the key-position only MSA and structural mapping of the key positions for FAK and BRD4.

In (b) and (c), cyan represents the structure of CRBN; purple represents the structure of FAK and BRD4; yellow balls and sticks represent PROTACs for FAK and BRD4; green balls and sticks represent the predicted key positions.

Fig 4

doi: https://doi.org/10.1371/journal.pcbi.1010974.g004