Metheor: Ultrafast DNA methylation heterogeneity calculation from bisulfite read alignments
Fig 3
Characteristics of LPMD across 928 cancer cell lines.
(A) Genomewide average methylation levels and LPMD levels grouped by tissue types. Black vertical lines denote groupwise average levels of methylation and LPMD levels. Black horizontal bars on the right side denote the standard deviation of corresponding values. (B) Genomewide average methylation levels and LPMD levels grouped by disease types. Disease types from haematopoietic and lymphoid tissues are highlighted in red. (C, D) Correlation between mRNA expression and (C) genomewide average LPMD or (D) genomewide average methylation level. Genes are ranked according to the p-values of the corresponding correlation coefficients. P-values were adjusted using Benjamini-Hochberg procedure. (E, F) Correlation between DNMT3A expression and (E) genomewide average LPMD or (F) genomewide average methylation level. (G, H) Trends of fixed-distance average LPMD values. Shades denote 95% confidence interval. In (H), Cell lines were divided into two groups based on the median DNMT3A expression. (I) Difference of fixed-distance average LPMD values between DNMT3AHigh and DNMT3ALow groups.