Physics-based tissue simulator to model multicellular systems: A study of liver regeneration and hepatocellular carcinoma recurrence
Fig 8
Predictions of a 50% PH compared to the outcomes of 30% and 70% PH.
(a) Fold-increase in the liver volume after 30% (violet), 50% (orange) and 70% (green) PH. Black dots represent the time at which the volume increase reaches a plateau and the red dotted line is a polynomial fitting. (b) Percentage of hepatocytes that proliferates during liver regeneration. Black dots represent the time at which the proliferation increase reaches a plateau. Inset: Proliferation percentage in terms of the PH. The red dotted line represents a polynomial fitting. Shaded regions represent the standard deviations of 40 simulations.