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Physics-based tissue simulator to model multicellular systems: A study of liver regeneration and hepatocellular carcinoma recurrence

Fig 2

Main loop flow diagram.

Blue box represents the start of the program. Red box represent the diffusion processes. Green box and orange box describe the cell mechanics and cycling processes respectively. Finally, yellow boxes represent the data saving process. After initializing the microenvironment, the cells, and the current simulation time t = 0, our model tracks (internally) tmech (the next time at which cell mechanics methods are run), tcycle (the next time at which cell processes are run), and tsave (the simulation data output time), with output frequency Δtsave. % represents the modulo operation.

Fig 2

doi: https://doi.org/10.1371/journal.pcbi.1010920.g002