Enhanced viral infectivity and reduced interferon production are associated with high pathogenicity for influenza viruses
Fig 3
Comparison of estimated model parameters between HP and LP strains of the H1N1 viruses.
Histograms show the frequency of the ratios of estimated HP parameters over paired LP model parameters and are normalised to [0, 1]. The ratios are presented by distributions of 6000 samples because they are generated by 6000 posterior parameter values. The cumulative density functions (CDFs) are given by the solid lines, and the dashed lines indicate ratios = 0. All ratios are log10-scaled, such that ratios > 0 (dark green) suggest greater values of the HP parameters. Fig (A, B, C) show the ratios of viral infectivity, and interferon production rate from infected cells and activated macrophages, respectively. Fig (D, E, F) show the ratios of infection-induced macrophage recruitment rate, macrophage-mediated virus clearance rate and antibody neutralisation rate, respectively. The model parameter comparison for the H5N1 viruses is given in S4 Fig.