Modelling ribosome kinetics and translational control on dynamic mRNA
Fig 6
Synthesis rates for Coat and RdRp proteins in Bacteriophage MS2.
(A) Temporal dynamics of coat protein and RdRp synthesis from bacteriophage MS2 mRNA in a bacterial cell over 30 minutes. Red dashed line corresponds to the initial synthesis rate of RdRp before coat protein binding to the TR stem-loop (c.f. Fig 4A) suppresses further synthesis. (B) Maximal Coat and RdRp synthesis rates from bacteriophage MS2 mRNA as a function of coat hairpin unfolding time. The curve is computed by varying τu explicitly in the program, with dots representing the results from simulations with specific mutant sequences. Blue dashed line shows the ratio of RdRp to Coat protein synthesis rates.