Uncovering specific mechanisms across cell types in dynamical models
Fig 3
(A) A schematic representation of the structure of the model used in [27]. (B) A typical data realization (dots) with model fits before regularization (lines and shaded areas). (C) Parameter values used for simulation of the data for the five cell types. (D) Schematic representation of the simulation study work-flow. (E) The number of times each individual fold-change parameter and difference of fold-change parameters is constrained to zero in the parsimonious model is plotted as a histogram for the standard LASSO approach (blue) and the symmetric penalization of fold-change differences (red). A gray bin background indicates the true values that were used for simulation of the data.