Uncovering specific mechanisms across cell types in dynamical models
Fig 2
(A) Schematic representation of the model structure. Each arrow represents a degradation reaction in one of the three cell types. (B) Model parameter values used for simulation, i.e., the kinetic rate constants and initial concentrations used in the three cell types. (C) A typical data realization (means and error bars) with un-regularized model fits (lines). (D) Objective function landscapes with the regularized best-fit parameter vector (red dot) for different regularization strengths λ. Square brackets indicate a significant decrease in likelihood in terms of a likelihood ratio test.