Deciphering the RRM-RNA recognition code: A computational analysis
Fig 9
A) Cartoon representation of the MSI1 RRM1 protein in complex with GUAGU (G1 not shown, PDB Id. 2rs2). The protein backbone is shown in light blue and heavy atoms are shown in red (O atoms), blue (N atoms), Orange (P atoms), light blue (C atoms of RRM) and sea blue (C atoms of RNA). The RNA nucleotides and the residues involved in the specific recognition of G4 (K21 and F65) are shown as sticks and spheres. B) and C) Score matrices for the alignment positions matching the interactions between K21 and F65 with G4, respectively (highlighted in bright green).