Mechanisms of hemoglobin cycling in anemia patients treated with erythropoiesis-stimulating agents
Fig 6
Variability in hemoglobin and ESA administration dynamics for a simulated example patient and treatment setting, where individual physiological and treatment parameters are varied (continued).
All conventions identical to Fig 5. (A) Standard deviation of Hb levels, (A’) Correlation coefficient between simulated Hb measurements and ESA doses and (A”) mean ESA dose as a function of RBC lifespan. (B–D”) Contour plots show the indicated quantities if two parameters are varied simultaneously. Columns are organized by quantity displayed and rows are organized by pair of parameters varied. Hatched regions in panels B’ and C’ indicate parameter regions where the Hb-ESA correlation coefficient is not defined. Parameters not indicated are fixed to the values provided in Table 1.