Mechanisms of hemoglobin cycling in anemia patients treated with erythropoiesis-stimulating agents
Fig 3
Simulated hemoglobin dynamics display a steady or cycling behavior, respectively, depending on physiological and treatment parameters.
Plots show simulated ground-truth hemoglobin levels (gray curves), hemoglobin levels including simulated measurement errors (dots) and ESA administrations (bars). (A) Simulations with a reference parameter set (selected parameters shown above the plot, all other parameters given in Table 1). (B–D) Simulations with parameters varied with respect to the reference parameter set as indicated. In all panels, the shaded region indicates the hemoglobin target window that dose adjustments aim to reach. Initial conditions were drawn from the distribution of equilibrated states. See Methods for simulation details.