Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens
Fig 7
Pareto front optimization study simulating all 4–way combinations of HRZEM to find regimens that minimize both average sterilization time and total dose.
Pareto front optimization identifying optimal dose and sterilization times for: (A) HRZM, (B) HRME, (C) HMZE, (D) RMZE and (E) HRZE. In each panel (A–E), red dots represent the (non–dominating) regimens that belong to the Pareto set (see Tables B–F in S1 Appendix for the doses of each antibiotic in the regimens that belong to Pareto sets) whereas black dots are the regimens that are not optimal based on the objectives. Green dots show the regimen based on the current standard doses recommended by CDC [4]. (F) Pareto sets for all regimens (same as red dots in panels A–E) compared to the standard regimen HRZE with CDC–recommended doses (X in Panel F). Dots in the dashed gray rectangle indicate the regimens that have lower total drug dose and lower average sterilization times (see Table 2 for the doses of each antibiotic in these regimens). Triangles indicate optimized regimens with 3–way combinations, as the optimal doses of one antibiotic (E or Z) in these regimens are predicted as 0.