Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens
Fig 6
Simulated treatments with 4–way, 3–way, 2–way regimen comparison from HRZEM.
Comparison of (A–C) sterilizing rates and (D–F) sterilization times of all regimen combinations of HRZEM to HRZE (thick green curve in all panels) in (A and D) 100 high–CFU, (B and E) 100 low–CFU and (C and F) a combination of 100 high–and 100 low–CFU granulomas. Significance test was performed only between HRZE and all other regimens (*p<0.01, one–tailed paired t–test). The central lines in box plots represent the median, whereas the bottom and the top edges of boxes represent 25th and 75th percentiles, respectively. Colored curves indicate the regimens that clear granulomas faster than HRZE, i.e., they have a significantly lower sterilization times. Gray curves represent regimens with slower sterilization.