Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens
Fig 4
Comparison of metabolic activity (measured by SUVR) change post treatment in NHP and GranSim.
Comparison of metabolic activity changes (A) in NHP granulomas and (B) using GranSim. (A) Change in standardized uptake value ratio (SUVR) per NHP granuloma (colored dots) in 8 weeks (SUVR8weeks−SUVRpre–treatment) when NHP are treated with HRZE (n = 3 animals), HMZE (n = 4 animals) and RMZE (n = 2 animals) for 8 weeks (n = 7 animals in control case, i.e., without treatment). Color shades of the dots in each column indicate NHPs and the diamonds are the median of SUVR change/granuloma for each NHP. (B) Change in FDG avidity per granuloma simulated using GranSim (FDG avidity8weeks−FDG aviditypretreatment) averaged over 200 granulomas (*p<0.0005, one–tailed paired t–test). The central red lines in box plots represent the median, whereas the bottom and the top edges of boxes represent 25th and 75th percentiles, respectively.