Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens
Fig 3
Comparing NHP and GranSim regimens.
Comparison of the standard regimen (HRZE) to two moxifloxacin–containing regimens, HMZE and RMZE, between in silico studies with GranSim (panels A–C) and in vivo NHP studies (panels D and E). (A) The sterilization times of granulomas averaged over 200 granulomas in GranSim. Note that we assign the maximum simulation time of 60 days as a sterilization time for unsterilized granulomas (*p<0.001, one–tailed paired t–test). The central red lines in box plots represent the median, whereas the bottom and the top edges of boxes represent 25th and 75th percentiles, respectively. (B, E) Percentage of granulomas that are unsterilized by treatment end for (B) NHP studies and (E) GranSim. Colored dots in (E) represent the percentage of unsterilized granulomas per NHP. (C) The fraction of granulomas which are unsterilized as a function of simulated treatment time using GranSim. (D) The average total CFU per NHP after treatment with the corresponding regimens for two months (n = 7 animals in the control group, n = 3 animals in HRZE group, n = 4 animals in HMZE, n = 2 animals in RMZE). Statistical analyses were not performed on the NHP data due to small numbers of animals per group.