A quantitative model for human neurovascular coupling with translated mechanisms from animals
Fig 7
Model estimation and prediction of MR-based experimental data in humans for different visual stimulation tasks (Section 2.3).
The graph contains data for three different tasks: cerebral blood volume (CBV) (A), blood oxygen level dependent (BOLD) signal (D), and cerebral blood flow (CBF) (E) changes for small flickering checkerboard task, and compartment-specific CBV changes for an excitatory (B) and inhibitory (C) flickering tasks. For each graph, the stimulus duration (30 s) is depicted as the black bar in the bottom left portion of each graph. In A-E: experimental data shown with the measurement uncertainty as the standard error of the mean (SEM) (colored error bars); the best model simulations are seen as colored solid lines corresponding to respective measurement observables; the model uncertainty is depicted as colored semi-transparent overlays; the x-axis represents time in seconds, and the y-axis is the change in fractional (D, E) or percentual change (A–C) of the measurement observables. The model prediction uncertainty of CBF (E) and compartment-specific CBV changes (B, C) is depicted as semi-transparent overlays. The experimental time series are taken from Huber et al. [49]. Translated mechanistic insights are shown for the three arms of vascular control (F, G), hemoglobin dynamics (H, I), and local field potential (LFP) (J, K), for the positive (F, H, J), and negative (G, I, K) BOLD response. F-K are given as arbitrary units (A. U.).