A quantitative model for human neurovascular coupling with translated mechanisms from animals
Fig 6
Model estimation to experimental data from macaque primates (Section 2.2). We see blood oxygen level dependent (BOLD) (A) and electrophysiological (B) responses in macaques for two variants of a visual task. The visual task was 20 s long, for the positive task, and 21 s, for the negative task, visual stimulation of V1 in the visual cortex (marked with the black bar in the bottom left portion of each graph). In A & B: experimental data (colored “*”-symbols); the uncertainty of the experimental data is presented as the standard error of the mean (SEM) (colored error bars); the best model simulation is seen as colored solid lines corresponding to respective measurement observables. The model uncertainty is seen as the semi-transparent colored areas. The x-axis represents time in seconds, and the y-axis is BOLD signal change (Δ%) for A and local field potential (LFP) expressed as percent change from baseline (Δ%) for B. C-D: translated dynamics and mechanisms regarding the effect on the VSM from the different vasoactive substances: nitric oxide (NO), neuropeptide Y (NPY), and prostaglandin E2 (PGE2) given as arbitrary units (A. U.). E-F: translated dynamics from mice regarding the hemoglobin changes given as arbitrary units (A. U.).