A quantitative model for human neurovascular coupling with translated mechanisms from animals
Fig 5
Model estimation to experimental data of hemoglobin changes in mice for three different stimulation types (Section 2.1.4).
The experiment features optogenetic (OG) activation of inhibitory (A & D) and excitatory (B & E) neurons, and sensory stimulation (C & F). For each stimuli type, a short stimulus (OG: 100 ms of light (A-B); Sensory: 2 s I) and a long stimulus (OG: 20 s (D-E); Sensory: 20 s (F)) was used. This is denoted with the black bar in the bottom left portion of each graph. The shown experimental data are replotted versions of S5 Fig of the study by Desjardins et al. [48]. For A-F: experimental data consisting of oxygenated hemoglobin (HbO; dark-red symbols), deoxygenated hemoglobin (HbR; light-blue symbols), and total hemoglobin (HbT; green symbols); the uncertainty of the experimental data is presented as the standard error of the mean (SEM) (colored error bars); the best model simulation is seen as colored solid lines corresponding to respective measurement variable; the model uncertainty as colored semi-transparent overlays; the x-axis represents time in seconds, and the y-axis is the change in hemoglobin concentration (μM). G-I: preserved mechanisms i.e., correct relative timing, of the vasoactive effect on the VSM from the different vasoactive substances, nitric oxide (NO), neuropeptide Y (NPY), and prostaglandin E2 (PGE2). J: model predictions (shaded area) and experimental data (mean ± SEM, symbols) of a BOLD response to an identical stimulus is shown in E. The experimental data were extracted from Desjardins et al. 2019 [48].