Gene signature discovery and systematic validation across diverse clinical cohorts for TB prognosis and response to treatment
Fig 5
Model validation using the Catalysis TB treatment study.
(A) Comparison of TB scores generated by the reduced model at Day 0, 7, 28, and 168 after treatment initiation and from healthy controls are shown in a violin plot. Individual datapoints are plotted as a point in the violin plot (datapoints n = 395). (B) Receiver operating characteristic curves depict model discrimination between healthy controls and the patients from different time points after treatment initiation. Area under the curve and 95% confidence intervals for each interval to disease are also shown. (C) At each timepoint the TB scores were stratified by the time of sputum culture conversion to negative (negativity at day 28, 56, 84 and 168, and no conversion at day 168 [failed]) and plotted in the violin plot (datapoints n = 360). (D) ROC curves, stratified by different timepoints after treatment initiation, depict predictive performance of the models for discrimination between the patients with bacteriological cure and those with treatment failure at EOT. (E) Comparison of TB scores against treatment outcome from poorly compliant subjects at day 0. P–values were calculated using the Mann–Whitney U test (**, p < 0.01).