Gene signature discovery and systematic validation across diverse clinical cohorts for TB prognosis and response to treatment
Fig 4
Building a probabilistic TB risk model.
(A) The distributions of the full model–generated TB scores, stratified by categorical interval to disease, and active TB, are shown in the violin plot, based on the pooled dataset collected from all the 37 studies. Individual datapoints of the dataset are plotted as a point in the violin plot (datapoints n = 3869). (B) The 6 probability functions (cumulative distribution function) that depict the probabilities of the outcomes (HC, LTBI, < 24m, < 12m, < 3m to disease, and active TB) as a function of TB scores were showed in lines with different colors. The shaded area represented the 95% confidence interval area.