Tissue Forge: Interactive biological and biophysics simulation environment
Fig 10
Delta-Notch signaling in a cellular monolayer subject to environmental control via a soluble signal.
A: Lateral inhibition of Delta expression (cells with high Delta shown as red, cells with low Delta as blue) through contact-mediated Delta-Notch signaling without environmental regulation produces patterns in monolayers. Initially (left) Delta expression is approximately uniform but over time a pattern spontaneously emerges through contact-mediated signaling (right). B: Diffusion of a regulatory signal that induces Delta-Notch signaling along a uniform grid of particles representing point measurements of concentration. Initially (left) the cells are not exposed to the signal, but over time (right) the signal diffuses from the top boundary. C: When Delta-Notch signaling depends on induction via local concentration of the regulatory signal in B (not shown), pattern formation in the monolayer follows the propagation of the diffusive signal across the monolayer.