Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins
Fig 10
A model depicting how a combination of a weakly dimerising receptor and a crosslinking agent can drive cluster formation.
The key is shown on the upper right: (A) illustrates crosslinking of two phosphorylated receptors in such a way that growth can only occur through dissociation or addition of a divalent ligands (B) ligand-induced dimerisation of two crosslinked dimers (C) cluster growth by a dimerising receptor and crosslinker. This can be further increased in the presence of a divalent ligand.