Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins
Fig 5
An agent-based model showing that the degree of receptor dimerisation increases with receptor number and rate of association.
The effect of receptor number and rates of association and dissociation on receptor dimerisation (Eq 4.1) was modelled using an agent-based model. Unless stated, the parameter values and key are as described in Fig 4. (A) The effect of receptor number on formation of receptor dimers (i) representative runs at steady-state with the number of receptors shown in the upper right-hand corner (ii) the level of receptor dimerisation at steady-state (iii) the time course of receptor dimerisation. Results are shown as mean + s.d. of 30 simulations at 3,000 ticks. (B) The effect of varying the rate of receptor dimerisation (i) the rate of association is shown in the upper right-hand corner, for further details see part (A). (C) The effect of varying the off-rate of receptor dimerisation (i) the off-rate of association is shown in the upper right-hand corner, for further details see part (A).