Identifying a developmental transition in honey bees using gene expression data
Fig 7
Applying the Landau method to hepatocellular carcinoma data demonstrates its relationship with methods that rely on the increase of correlated fluctuations.
(A) Combining control samples from healthy livers with samples from various stages of liver cancer (data from Ref. [32]), we find increasingly strong evidence of bimodality starting at the “early HCC” stage. The SNE approach, designed to find evidence of transitions before they happen, identified critical fluctuations at the “very early HCC” stage [18]. (B) Along the bistable dimension, increasingly separate clusters of gene expression are visible. The ground-truth group membership of each sample is indicated by color: purple for control samples and orange for disease samples.