Identifying a developmental transition in honey bees using gene expression data
Fig 2
In honey bees, both the variance of gene expression and the strength of evidence for bistability grow over developmental time.
A: The standard deviation of gene expression along the principal component increases during development. Error bars show standard errors (Nsamples = 16). B: The Bayesian Information Criterion measure ΔBIC quantifies the strength of evidence in favor of the bistable transition distribution as compared to a unimodal Gaussian, with positive values favoring bistability (blue circles; see Methods Eq (16)). We interpret ΔBIC values larger than 6 (horizontal dashed line) as strong evidence for bistability. We also compute ΔBIC that compares a Gaussian mixture (n = 2) with the unimodal Gaussian, which identifies weaker evidence for bimodality (orange Xs; see section 3).