Stochastic modelling of a three-dimensional glycogen granule synthesis and impact of the branching enzyme
Fig 9
Comparison of simulated versus experimental CLDs.
Experimental data are from Sullivan and coworkers [25] (black squares). In each simulation run 50,000 glucose units are incorporated in the growing granule (grey line). The average over 200 runs is represented as a red dotted line. Left: The CLD for the best fitting score () is obtained with {Γ = 0.6,
,
,
, ρ = 0.65 nm}. Our best fit almost perfectly captures the experimental CLD. Right: CLD using parameter values typically assumed in the literature {Γ = 0.6,
,
,
, ρ = 0.65 nm} [49, 50]. The simulated CLD differs a lot from the experimental one, with under-representation of small DPs, and over-representation of high ones.