Stochastic modelling of a three-dimensional glycogen granule synthesis and impact of the branching enzyme
Fig 6
Dynamics of the occupancy profiles for a tightly (Γ = 0.2, Left) and sparsely (Γ = 10.0, Right) packed granule.
Occupancy as a function of the radius at different simulation times. Each line corresponds to an incorporation of N = 5,000 glucose units. The simulation stops at N = 50,000. The grey arrow highlights the two phases of the granule synthesis dynamics. In phase 1, steric hindrance constrains are low, allowing occupancy to increase. In phase 2, i.e. after incorporation of ca. N = 10,000 glucose units, the occupancy reaches a plateau and the granule expands.