Network models of protein phosphorylation, acetylation, and ubiquitination connect metabolic and cell signaling pathways in lung cancer
Fig 6
Heatmaps showing PTM sites in Clusters B and C.
In the left hand panels, sites whose median abundance ratio in drug-treated vs. control cells was at least 2.25-fold lower are blue and those that were at least 2.25-fold higher are yellow (black is below threshold). The right hand panels show the drug-treated to control ratio (median of samples in each group) for each PTM site (see key at bottom; black represents missing data). Sample groups are as in Fig 5. (A) Sites in cluster B changed at least 2.25-fold in at least one sample group that are found in focal adhesions and/or are involved in actin dynamics. (B) Heatmaps of all PTM sites in Cluster C. Many of these sites are involved in regulation of transcription and/or are histone subunits. Sample groups: h3122.criz: H3122 cells treated with crizotinb; pc9.erl: PC9 cells treated with erlotinib.