Network models of protein phosphorylation, acetylation, and ubiquitination connect metabolic and cell signaling pathways in lung cancer
Fig 2
Pathway crosstalk networks with the EGF/EGFR signaling pathway.
(A) Three pathways linked by strong PTM cluster weight (purple edges). Note that the EGF/EGFR signaling pathway has no genes in common with Glycolysis and gluconeogenesis and Transmembrane transport of small molecules, but the latter two pathways have 11 genes in common (green edges represent pathway Jaccard similarity). (B) Nearest neighbors of pathways in A (★) with additional edges filtered to show only strong associations (PTM cluster weight > 0.065 and/or pathway Jaccard similarity > 0.5).