Computational analysis of 5-fluorouracil anti-tumor activity in colon cancer using a mechanistic pharmacokinetic/pharmacodynamic model
Fig 6
The simulation results associated with the four novel dosage regimens.
The regimens under consideration are (A) 100 mg/kg on day 1 of weeks 1 to 6 of a eight-week cycle, for a total of 4 cycles; (B) 50 mg/kg twice a week of weeks 1 to 6 of a eight-week cycle, for a total of 4 cycles; (C) 100 mg/kg on day 1 of weeks 1 to 3 followed by 50 mg/kg twice a week of weeks 4 to 6, for a total of 4 cycles (32 weeks); (D) 50 mg/kg twice a week of weeks 1 to 3 followed by 100 mg/kg on day 1 of weeks 4 to 6, for a total of 4 cycles (32 weeks). Red dash line: model simulation of control; blue solid line: simulation results associated with the four dosage regimens; purple diamond-shaped dot: time of injection of 100 mg/kg 5FU; green round dot: time of injection of 50 mg/kg 5FU.